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STUDY ON THE CLINICAL EFFECTS IN TREATMENT OF STOMACH DISEASES OF THE PRODUCT NAMED DOM KIM HOAN VIEN MAT NGHE (CAPSULE MADE UP OF PIG BILE AND TURMERIC)

In recent years, stomach diseases have alarmingly been developing at an alarming rate. According to statistics of the Vietnam Association of Gastroenterology (VNAGE), about 70% of the population is at risk of contracting stomach disease. This disease is the most popular one among gastrointestinal diseases, accounting for 26% of total number of gastrointestinal disease cases and this figure is likely to increase more and more.

At present, there are many Western medicines available to treat this disease. However, generally these drugs are expensive and can cause digestive disorders and other side effects when used for a long time. Thus, people tend to choose products derived from the nature like in the past. The Dom kim hoan medication published by Late Prof. Le Minh Xuan is made up of three herbs, Rhizoma Curcumae longae (turmeric), Pericarpium Citri reticulatae perenne (Citrus deliciosa Tenore), and Extractum Fellis (pig bile), which meets the demand for medicinal herbs and helps avoid unwanted effects in course of treatment using Western medicines.

According to the book “Vietnamese medicinal plants and drugs” of the author Do Tat Loi:

  • Turmeric contains active ingredient of curcumin that has anti-inflammatory, anti-bacterial effects, helps increase biliary secretion, improve the body's ability to digest fats, thereby preventing peptic ulcer and digestive disorders.
  • Pig bile contains mainly cholate salts and some bile pigments such as bilirubin that stimulate intestinal peristalsis, boost absorption in the duodenum, stimulate bile production and promote bile flow. Thanks to the above functions, apart from the effects of the bile, pig bile also acts as a stimulant in cases of biliary disorders and digestive disorders, impaired liver and pancreas functions, constipation accompanied by negative fermentation.

According to the book “Medicinal plants and animals in Vietnam“ (National Institute of Medicinal Materials):

  • Citrus deliciosa Tenore helps treat indigestion, belching, abdominal pain, poor digestion, vomiting, cough causing chest pain, phlegm.

Based on the traditional medicines of Late Prof. Le Minh Xuan and advanced technology to optimize product quality, OPC Pharmaceutical Joint Stock Company has researched and manufactured DOM KIM HOAN Vien Mat Nghe.

Ingredients in 1 capsule of DOM KIM HOAN Vien Mat Nghe:
Rhizoma Curcumae longae……………… ………………….......250.0mg
Pericarpium Citri reticulatae perenne…………………….............50.0mg
Extractum Fellis……………………………………........................25.0mg

To confirm the safety and effectiveness of the product and build trust among patients and doctors, OPC has made big investments in clinical studies to prove the effectiveness of the product “DOM KIM HOAN Vien Mat Nghe” on patients suffering from stomach diseases. The studies were conducted in collaboration with the Traditional Medicine Institute in March 2002.

   This study involves male and female patients with stomach disease in accordance with prescribed standards, aged 17-60, taking “DOM KIM HOAN Vien Mat Nghe” twice a day, two capsules per time before breakfast and dinner for 15 consecutive days and not taking any other medications used for treatment of the stomach disease during the study. Symptoms were assessed mainly at two points of time, on the 8th and 16th days:

After 7 days of treatment:
  • Significantly improve “epigastric pain”: up to 73.33% of the subjects observed improvement
  • Significantly improve “belching and epigastric soreness”: up to 73 % of the subjects observed improvement   
  • Significantly improve “indigestion”: up to 70 % of the subjects observed improvement   
  • Significantly improve “Flatulence, distended abdomen”: up to 70 % of the subjects observed improvement   
  • Significantly improve “Loss of appetite”: up to 70 % of the subjects observed improvement    
  • Significantly improve “Constipation”: up to 70 % of the subjects observed improvement    
After 15 days of treatment:
  • Significantly improve “epigastric pain”: up to 80% of the subjects observed improvement
  • Significantly improve “belching and epigastric soreness”: up to 73 % of the subjects observed improvement (of which, there is a change in good improvement ratio and rather good improvement ratio with 54.54% and 18.18% respectively)   
  • Significantly improve “indigestion”: up to 80% of the subjects observed improvement   
  • Significantly improve “Flatulence, distended abdomen”: up to 85% of the subjects observed improvement   
  • Significantly improve “Loss of appetite”: up to 80 % of the subjects observed improvement    
  • Significantly improve “constipation”: up to 83.33% of the subjects observed improvement    

During the study, the product did not alter bilirubin content, GOT and GPT activities in patients with these components at normal levels, it also did not damage liver and bile functions.

In addition, for patients with high total, direct, indirect bilirubin, and high GOT, GPT activities, after taking the drug and completing treatment, levels of such components reduced to normal levels.

The above findings are the important evidence proving that the “DOM KIM HOAN Vien Mat Nghe” of OPC Pharmaceutical Joint Stock Company helps treat symptoms such as epigastric pain, belching and epigastric soreness, poor digestion, flatulence, distended abdomen and has good effects on the symptoms: constipation, loss of appetite because Dom kim hoan stimulates appetite. However, minimal treatment time is 7 consecutive days and ideal treatment time is more than 15 consecutive days.

Besides DOM KIM HOAN Vien Mat Nghe, OPC has produced film-coated tablets of CHOLAPAN Vien mat nghe with the same ingredients of turmeric, Citrus deliciosa Tenore and pig bile.

Compared with film-coated tablets of CHOLAPAN Vien mat nghe, DOM KIM HOAN Vien mat nghe has the following advantages:

It is a traditional form of formulation from the traditional medicine, which tends to be closer to the nature than other forms of formulation and solid medications in general. Therefore, it is suitable for treatment of chronic diseases, intestinal diseases or when there is a need for providing additional nutrients for the body.

The product has form of formulation similar to formulation of solid medications in traditional medicine: only containing natural medicinal materials, adjuvants, condensed honey, and a small amount of adjuvants to help improve its organoleptic characteristics. Thanks to the modern machineries and equipment of OPC, the quality of solid medications has been higher, and their effects are increasingly improved.

Moreover, the condensed honey in the formula of a solid medication facilitates adjuvants’ ability to stick to drug powder, shaping the table; besides, it also helps treat and acts as a conductor to regulate the taste of the drug, protect the product from microorganisms and molds.

DOM KIM HOAN Vien mat nghe is an useful and valuable gift for human’s health, and is a natural product that helps recover and improve health in modern life today.

 2899   02/08/2018
Pharmacist Do Tung Uyen
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