PICADO®

FORMULA:

For 1 tube
– Active pharmaceutical ingredients:
Rhubarb alcoholic extract 3.8 ml
Equivalent to Rhubarb (Rhizoma Rhei) 500.0 mg
Salicylic Acid 100.0 mg
– Excipient:
Sodium carboxymethylcellulose, sodium saccharin, glycerine, peppermint essential oil, purified water.

DOSAGE FORM:

Gels.

Product description: Transparent brown gel, sweet, astringent, slightly acrid taste.

INDICATIONS:

Topical treatment of inflammatory lesion restricted to mucous membranes in the mouth and aphthae. For the symptomatic relief of pain associated with recurrent mouth ulcer and denture irritation.

DOSAGE AND ADMINISTRATION:

Apply the medicine to the wound 2 – 3 times per day. Put a small amount of gel the lesion and massage gently.

Do not rinse teeth or mouth immediately after application.

Or follow your doctor’s instructions.

CONTRAINDICATIONS:

Children under 6 years of age.

Children with a history of epileptic or convulsion because of high fever.

People with a history of stomach ulcers.

Reactions with salicylate derivatives may occur.

Do not apply to the eyes and open wounds.

People with hypersensitivity to any ingredient of the medicine.

WARNINGS AND PRECAUTIONS:

In case of signs of systemic infection, treatment with antibiotics is required.

Use with caution in pregnant women and lactating women.

Do not use high concentrations of the drug on a large area for a long time to avoid excessive absorption causing systemic side effects.

PREGNANT WOMEN AND LACTATING WOMEN:

Ask your doctor before use. There have been no reports of topical treatments containing Rhubarb such as Picado in pregnant women, but extreme caution should be exercised when prescribing. Anthranoid glycosides from Rhubarb can be excreted in breast milk, but there are no specific studies on the therapeutic dose of Picado, so only use it when the drug has more benefits for the mother than breastfeeding.

DRIVING AND OPERATING MACHINE ABILITY:

No effect.

DRUGS INTERACTIONS, DRUGS INCOMPATIBILITIES:

a) Drugs interactions:

Not reported yet.

b) Drugs incompatibilities:

Because there have not been any studies about incompatibilities of the drug, do not mix with other drugs.

UNDESIRABLE EFFECTS:

Teeth may be stained yellow, but this color will disappear quickly.

Transient burning sensation at the site of application.

Hypersensitivity reactions (hives or rash) occur very rarely.

Inform the doctor or the pharmacist immediately if any undesirable effect occurs while taking this medicine.

OVERDOSE AND TREATMENT OF OVERDOSE:

Symptoms: In case of swallowing too much medicine, there may be symptoms of acute diarrhea due to the laxative effect of Rhubarb and symptoms of salicylic acid poisoning: symptoms often vary depending on each person such as deep, rapid breathing, tinnitus, deafness, vasodilation, sweating.

Treatment: You should drink plenty of water, rehydrate and electrolyte compensation in case of acute diarrhea. In case of salicylic acid poisoning, gastric lavage and monitoring of plasma pH, plasma salicylate concentration and electrolytes should be monitored..

PHARMACOKINETIC:

Rhubarb has the effect of clearing heat, detoxifying, and antibacterial, and is a medicine commonly used to treat cases of swelling in the throat, mouth, sore gums, and pimples..

Salicylic acid is an antifungal, mild antiseptic and has the effect of peeling off the horny layers of the skin.

PHARMACODYNAMIC:

Some pigments in Rhubarb are absorbed into the blood and excreted through urine, sweat, and milk, creating a yellow color.

Salicylic acid is easily absorbed through the skin and slowly excreted in the urine.

PRESENTATION:

Box of tube of 10 g.

STORAGE:

In a dry place, do not store above 30°C, protected from light.

SHELF LIFE:

36 months from manufacturing date.

SPECIFICATION:

Manufacturer’s.